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Helping Healthcare Professionals Optimize Outcomes in KIT+ Gastrointestinal Stromal Tumor (GIST) Patients
 
GIST Treatment Support Program

Novartis, the global leader in KIT+ GIST therapy, has been working with healthcare professionals and patients worldwide to help improve the treatment of KIT+ GIST.

Novartis introduces KIT+ GIST Alliance™, a unique support program designed to help healthcare professionals optimize outcomes in KIT+ GIST patients.

GISTs are currently the most common mesenchymal tumors of the gastrointestinal tract, with an estimated 3300 to 6000 new cases reported each year in the United States.1,2 Approximately 2500 of these cases are metastatic at diagnosis.3

Diagnosis of Gastrointestinal Stromal
Tumors (GISTs)

The diagnosis of KIT+ GIST can be determined with immunohistochemical staining. More recently, identification of specific KIT mutations have been shown to have prognostic value in GISTs.

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Evaluating Response to Treatment in GIST

RECIST criteria have been shown to be inadequate in evaluating the response of GISTs to targeted therapy.

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Blood Level Testing and Gastrointestinal Stromal Tumors

Therapeutic drug monitoring can be useful to establish a baseline, monitor adherence, and optimize dosing of TKIs/KIT inhibitors. This can be particularly valuable in patients who are not responding or experiencing side effects.

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  1. Corless CL, Heinrich MC. Molecular pathobiology of gastrointestinal stromal sarcomas. Annu Rev Pathol Mech Dis. 2008;3:557-586.
  2. Demetri GD, Benjamin RS, Blanke CD, et al. NCCN task force report: management of patients with gastrointestinal stromal tumor (GIST)—update of the NCCN clinical practice guidelines. J Natl Compr Canc Netw. 2007;5(suppl2):S1–S29.
  3. Griffin JM, St Amand M, Demetri GD. Nursing implications of imatinib as molecularly targeted therapy for gastrointestinal stromal tumors. Clin J Oncol Nurs. 2005;9(2):161-169.

Enroll in the
GIST Registry, an
observational database
designed to collect data
on patients with GIST.

 
 
PK Blood Level Testing Services Provided Through a GIST Alliance Partner
 Avantix Free GIST Blood Testing Enrollment

Go to the Avantix partner website to enroll your patients in the program and order free testing kits.
Avantix Free GIST Blood Testing Enrollment

Radiologic evaluation of GIST